Small-Molecule-Mediated OGG1 Inhibition Attenuates Pulmonary Inflammation and Lung Fibrosis in a Murine Lung Fibrosis Model

Scientists showed that 8-oxoguanine DNA glycosylase-1 (Ogg1)-targeting siRNA mitigated bleomycin-induced pulmonary fibrosis in male mice, highlighting OGG1 as a tractable target in lung fibrosis.