RBM3 Suppresses Stemness Remodeling of Prostate Cancer in Bone Microenvironment by Modulating N6-Methyladenosine on CTNNB1 mRNA

By co-culturing prostate cancer cells (PCa) with osteoblasts to mimic PCa bone metastases, scientists found that RNA binding motif 3 upregulated the N6-methyladenosine methylation on the mRNA of catenin beta 1 in a manner dependent on methyltransferase 3.