RRP15 Deficiency Induces Ribosome Stress to Inhibit Colorectal Cancer Proliferation and Metastasis via LZTS2-Mediated β-Catenin Suppression

Scientists found that RRP15, a nucleolar protein critical for RiBi and checkpoint control, was frequently upregulated in primary colorectal cancers (CRCs), and higher RRP15 expression positively correlated with TNM stage and poor survival of CRC patients.