Spinal Cord Extracts of Amyotrophic Lateral Sclerosis Spread TDP-43 Pathology in Cerebral Organoids

The authors injected postmortem spinal cord protein extracts individually from three non-Amyotrophic lateral sclerosis (ALS) or five sporadic ALS patients, containing pathogenic TDP-43 into the cerebral organoids to validate the templated propagation and spreading of TDP-43 pathology in human central nervous system tissue.