Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension

The functional and molecular link between loss of bone morphogenetic protein receptor 2 (BMPR2) in pulmonary artery smooth muscle cells and pulmonary arterial hypertension pathogenesis was investigated, as most previous studies focused on BMPR2 in pulmonary artery endothelial cells.