Cre Recombinase Expression Cooperates with Homozygous FLT3 Internal Tandem Duplication Knockin Mouse Model to Induce Acute Myeloid Leukemia

Expression of various Cre recombinases led to polyclonal expansion of FLT3ITD/ITD progenitor cells, induction of a differentiation block, and activation of Myc-dependent gene expression programs.