Mesenchymal Stem Cell Suppresses the Efficacy of CAR-T toward Killing Lymphoma Cells by Modulating the Microenvironment through Stanniocalcin-1

Investigators reported that CAR-T cell-mediated cytotoxicity was significantly inhibited in the presence of MSCs. MSCs caused an increase of CD4+ T cells and Treg cells but a decrease of CD8+ T cells.