Mapping the 3D Remodeling of the Extracellular Matrix in Human Hypertrophic Scar by Multi-Parametric Multiphoton Imaging Using Endogenous Contrast

The authors performed label-free multiphoton microscopy of both fiber components from human skin specimens and propose a multi-fiber metrics analysis model for mapping the structural remodeling of the ECM in hypertrophic scars in a highly-sensitive, 3D manner.