CYB5R3 in Type II Alveolar Epithelial Cells Protects against Lung Fibrosis by Suppressing TGF-β1 Signaling

Scientists showed that expression of membrane-bound cytochrome B5 reductase 3 (CYB5R3), an enzyme critical for maintaining cellular redox homeostasis and soluble guanylate cyclase heme iron redox state, was diminished in idiopathic pulmonary fibrosis Type II alveolar epithelial cell.