AKT Phosphorylates FAM13A and Promotes Its Degradation via CUL4A/DDB1/DCAF1 E3 Complex

Researchers reported that FAM13A was phosphorylated at the Serine 312 residue by AKT kinase after cigarette smoke extract treatment and thereby recognized by the CULLIN4A/DCAF1 E3 ligase complex, rendering the ubiquitination-mediated degradation of FAM13A.