BMP4-SMAD1/5/9-RUNX2 Pathway Activation Inhibits Neurogenesis and Oligodendrogenesis in Alzheimer’s Patients’ iPSCs in Senescence-Related Conditions

The authors generated a cellular model that recapitulated neurogenesis defects observed in patients with Alzheimer’s disease (AD), using iPSC lines derived from sporadic and familial AD.