Heparan Sulfate Regulates IL-21 Bioavailability and Signal Strength that Control Germinal Center B Cell Selection and Differentiation

Scientists demonstrated that the follicular helper T (TFH) cell effector cytokine interleukin-21 (IL-21) joined BCR and CD40 in supporting BGC selection, and revealed that strong IL-21 signaling prioritized antibody-secreting cell differentiation in vivo.