Selective and Brain-Penetrant Lanosterol Synthase Inhibitors Target Glioma Stem-Like Cells by Inducing 24(S), 25-Epoxycholesterol Production

The authors investigated the mechanism of MM0299, a tetracyclic dicarboximide with anti-glioblastoma activity. MM0299 inhibited lanosterol synthase and diverted sterol flux away from cholesterol into a “shunt” pathway that culminated in 24(S),25-epoxycholesterol.