Tyrosine Kinase Receptor B (TrkB) Attenuates Liver Fibrosis via Inhibiting TGF-β/SMAD Signaling

TrkB suppressed TGFβ-stimulated proliferation and activation of hepatic stellate cells (HSCs) and in 3D liver spheroids and significantly repressed TGF-β/SMAD signaling pathway either in HSCs or in hepatocytes.