Targeting ACE2-BRD4 Crosstalk in Colorectal Cancer and the Deregulation of DNA Repair and Apoptosis

Scientists reported that knockdown, forced overexpression, and pharmacologic inhibition of angiotensin I-converting enzyme 2 (ACE2) in human colon cancer cells targeted (ACE2)-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis.