METTL14-Dependent Maturation of Pri-miR-17 Regulates Mitochondrial Homeostasis and Induces Chemoresistance in Colorectal Cancer

Investigators found that overexpression of miR-17-5p led to less apoptosis and lower drug sensitivity in vitro and in vivo under the 5-fluorouracil (5-FU) treatment, which indicated miR-17-5p led to 5-FU chemotherapy resistance.