A Zeb1/MtCK1 Metabolic Axis Controls Osteoclast Activation and Skeletal Remodeling

While attempting to identify new regulatory molecules critical to bone resorption, scientists discovered that murine and human osteoclast differentiation is accompanied by the expression of Zeb1, a zinc-finger transcriptional repressor whose role in normal development is most frequently linked to the control of epithelial-mesenchymal programs.