PI3-Kinase Deletion Promotes Myelodysplasia by Dysregulating Autophagy in Hematopoietic Stem Cells

By
Noshin Noorjahan
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To determine whether phosphatidylinositol 3 kinase (PI3K) down-regulation can perturb HSC function, scientists generated a triple knockout mouse model with Pik3ca, Pik3cb, and Pik3cd deletion in hematopoietic cells.
[Science Advances]
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