Activation of ERK1/2 by MOS and TPL2 Leads to Dasatinib Resistance in Chronic Myeloid Leukemia Cells

The authors investigated the mechanism of breakpoint cluster region::Abelson murine viral homologue 1-independent dasatinib resistance. The expression and activation level of genes or proteins were evaluated using array CGH, real time PCR, or western blot analysis.