Exploiting the Receptor-Binding Domains of RSPO1 to Target LGR5-Expressing Stem Cells in Ovarian Cancer

In order to target stem cells in ovarian cancer, scientists used the sortase reaction to site-specifically conjugate the potent cytotoxin monomethyl auristatin E and their co-receptors ZNRF3 and RNF43 via a protease-cleavable linker.