16p11.2 Deletion Accelerates Subpallial Maturation and Increases Variability in Human iPSC-Derived Ventral Telencephalic Organoids

Using ventral telencephalic organoids derived from human iPSCs, scientists investigated the effect of 16p11.2 microdeletion on organoid size, progenitor proliferation and organisation into neural rosettes, ganglionic eminence marker expression at early developmental timepoints, and expression of the neuronal marker NEUN at later stages.