MicroRNA 483–3p Overexpression Unleashes Invasive Growth of Metastatic Colorectal Cancer via NDRG1 Downregulation and Ensuing Activation of the ERBB3/AKT Axis

Taking advantage of a large panel of human metastatic colorectal cancer xenografts and matched stem-like cell cultures, researchers showed that overexpression of microRNA 483-3p, encoded by a frequently amplified gene locus, confered an aggressive phenotype.