Niclosamide Inhibits Epithelial-Mesenchymal Transition with Apoptosis Induction in BRAF/ NRAS Mutated Metastatic Melanoma Cells

Researchers found that niclosamide induces significant ROS generation and apoptosis through a series of molecular mechanisms, such as depolarization of mitochondrial membrane potential, arresting the cell cycle at the sub G1 phase with a significant increase in the DNA cleavage via topoisomerase II in both cell lines.