Fibroblast Growth Factor 18 Alleviates Stress-Induced Pathological Cardiac Hypertrophy in Male Mice

FGF18 heterozygous (Fgf18+/−) and inducible cardiomyocyte-specific FGF18 knockout male mice exposed to transverse aortic constriction demonstrated exacerbated pathological cardiac hypertrophy with increased oxidative stress, cardiomyocyte death, fibrosis, and dysfunction.