Synovial Mesenchymal Stem Cell-Derived Exosomal MicroRNA-320c Facilitates Cartilage Damage Repair by Targeting ADAM19-Dependent Wnt Signaling in Osteoarthritis Rats

After four weeks of destabilization of the medial meniscus surgery to establish an osteoarthritis model, the rats received weekly articular cavity injection of SMSCs with or without GW4869 treatment or exosomes from SMSCs with or without microRNA-320c overexpression for another four weeks.