RELA Tunes Innate-Like Interferon I/III Responses in Human T Cells

Scientists identified a transcriptional rheostat orchestrated by RELA that conferred human T cells with innate-like abilities to produce IFN-I/III. Despite intact cGAS-STING signaling, IFN-I/III responses were stunted in CD4+ T cells, compared with dendritic cells or macrophages.