Nicotine Reduces ROS and Enhances Cell Proliferation via the α4 Nicotinic Acetylcholine Receptor Subunit in Human Induced Pluripotent Stem Cells

After expression levels of nicotinic acetylcholine receptor (nAChR) subunits in hiPSCs were determined, the effects of the nAChR agonist, nicotine, on undifferentiated hiPSCs were evaluated using a Clariom S Array. Investigators also determined the effect of nicotine alone and with a nAChR subunit antagonist on hiPSC cells.