Subscribe
e.g. organoids

Single-Cell Transcriptomic Atlas-Guided Development of CAR-T Cells for the Treatment of Acute Myeloid Leukemia

Functional validation of established CAR-T cells shows robust in vitro and in vivo efficacy in cell line- and human-derived acute myeloid leukemia models with minimal off-target toxicity toward relevant healthy human tissues.
[Nature Biotechnology]
Full Article
Published In
NewslettersCell Therapy News
spot_img

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News

RB1-Deficient Prostate Tumor Growth and Metastasis Are Vulnerable to Ferroptosis Induction via the E2F/ACSL4 Axis

[Journal Of Clinical Investigation] Researchers showed that RB1-loss/E2F activation sensitized cancer cells to ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, by upregulating expression of ACSL4 and enriching ACSL4-dependent arachidonic acid-containing phospholipids, which are key components of ferroptosis execution.
NewslettersProstate Cell News
Read more

Expression and Therapeutic Targeting of Trop-2 in Treatment Resistant Prostate Cancer

[Clinical Cancer Research] Scientists observed that Trop-2 can serve as a cell surface target for isolating circulating tumor cells, which may serve as a predictive biomarker for antibody drug conjugates.
NewslettersProstate Cell News
Read more

CD46 Targeted 212Pb Alpha Particle Radioimmunotherapy for Prostate Cancer Treatment

[Journal Of Experimental & Clinical Cancer Research] Investigators reported the development of a novel CD46-targeted alpha therapy based on the internalizing human monoclonal antibody, YS5.
NewslettersProstate Cell News
Read more
Brought to you by