Inhibition of Mammalian Target of Rapamycin Complex 1 in the Brain Microvascular Endothelium Ameliorates Diabetic Aβ Brain Deposition and Cognitive Impairment via the Sterol-Regulatory Element-Binding Protein 1/Lipoprotein Receptor-Associated Protein 1 Signaling Pathway
In vitro, brain microvascular endothelial cells were cultured with high glucose, and the activation of mTORC1 and sterol-regulatory element-binding protein 1 was observed.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.