Inhibition of Mammalian Target of Rapamycin Complex 1 in the Brain Microvascular Endothelium Ameliorates Diabetic Aβ Brain Deposition and Cognitive Impairment via the Sterol-Regulatory Element-Binding Protein 1/Lipoprotein Receptor-Associated Protein 1 Signaling Pathway
In vitro, brain microvascular endothelial cells were cultured with high glucose, and the activation of mTORC1 and sterol-regulatory element-binding protein 1 was observed.
[Haematologica] 301 patients with a median age 60 years were enrolled. Of them, 287 and 274 patients collected ≥2 and ≥4×106 CD34+ cells/kg, respectively, with a median of 9.9×106 CD34+ cells/kg collected.
[EMBO Journal] The authors provide an in-depth review of the metabolic and epigenetic interplay regulating hematopoietic stem cell fate, and discuss the influence of metabolic stress stimuli, as well as alterations occurring during leukemic development.