LINC00659 Exacerbates Endothelial Progenitor Cell Dysfunction in Deep Vein Thrombosis of the Lower Extremities by Activating DNMT3A-Mediated FGF1 Promoter Methylation
A total of 30 inferior vena cava tissue samples and peripheral blood were obtained from lower extremity deep venous thrombosis patients and healthy donors, and then LINC00659 expression was detected by RT-qPCR.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.