Investigators found that TRPV4 expression in mouse glomerular endothelial cells (MGECs) increased after lipopolysaccharide stimulation or cecal ligation and puncture challenge, which increased intracellular Ca2+ in MGECs.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.