Pax4-Ghrelin Mediates the Conversion of Pancreatic Ɛ-Cells to β-Cells after Extreme β-Cell Loss in Zebrafish
Using a zebrafish nitroreductase (NTR)-mediated β-cells ablation model, the authors uncovered that ghrelin-positive ɛ-cells in the pancreas acted as contributors to neogenic β-cells after extreme β-cell loss.
[Signal Transduction and Targeted Therapy] Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Science of The Total Environment] RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Cell Reports] The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.