UBE2K Regulated by IGF2BP3 Promotes Cell Proliferation and Stemness in Pancreatic Ductal Adenocarcinoma
Investigators discovered that ubiquitin‑conjugating enzyme E2K (UBE2K) was expressed at high levels and indicated the poor prognosis of patients with PDAC.
[Signal Transduction and Targeted Therapy] Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Science of The Total Environment] RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Cell Reports] The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.