Overexpression of Tripartite Motif-Containing 47 (TRIM47) Confers Sensitivity to PARP Inhibition via Ubiquitylation of BRCA1 in Triple Negative Breast Cancer Cells

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Researchers showed that overexpression of TRIM47 correlated with progression and poor prognosis in TNBC. They demonstrated that TRIM47 directly interacted with breast cancer susceptibility gene 1 (BRCA1) and induced ubiquitin-ligase-mediated proteasome turnover of BRCA1.
[Oncogenesis]
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