Overexpression of Tripartite Motif-Containing 47 (TRIM47) Confers Sensitivity to PARP Inhibition via Ubiquitylation of BRCA1 in Triple Negative Breast Cancer Cells

Researchers showed that overexpression of TRIM47 correlated with progression and poor prognosis in TNBC. They demonstrated that TRIM47 directly interacted with breast cancer susceptibility gene 1 (BRCA1) and induced ubiquitin-ligase-mediated proteasome turnover of BRCA1.