Overexpression of the Telomerase Holoenzyme Induces EMT and Tumorigenesis of HPV-Immortalized Keratinocytes

The authors questioned whether increases in telomerase components might mediate the acquisition of the tumorigenic phenotype. They therefore transduced the TERT and TERC genes into E6/E7 immortalized keratinocytes that were anchorage-dependent and non-tumorigenic.