Keratinocytes Sense and Eliminate CRISPR DNA through STING/IFN-κ Activation and APOBEC3G Induction

CRISPR-generated KO keratinocytes had permanent suppression of IFN-κ and IFN-stimulated gene expression, secondary to hypermethylation of the IFNK promoter region by the DNA methyltransferase DNMT3B.