Activating Wnt/β-Catenin Signaling by Autophagic Degradation of APC Contributes to the Osteoblast Differentiation Effect of Soy Isoflavone on Osteoporotic Mesenchymal Stem Cells

Scientists showed that genistein, a predominant soy isoflavone, stimulated osteoblast differentiation of MSCs in vivo and in vitro. Female rats were subjected to bilateral ovariectomy; four weeks after surgery the rats were orally administered genistein for eight weeks.