SREBP2 Maintains Glioblastoma Stem Cells through Keeping the Balance between Cholesterol Biosynthesis and Uptake Get Access Arrow

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Researchers investigated the adaptive behavior of glioblastoma stem cells under different cholesterol supplies. In vitro and in vivo loss-of-function genetic and pharmacologic assays were conducted to evaluate the effect of Sterol Regulatory Element-Binding Protein 2 (SREBP2) on glioblastoma cholesterol biosynthesis, proliferation, and self-renewal.
[Neuro-Oncology]
Abstract