Lost in Local Translation: TDP-43 and FUS in Axonal/Neuromuscular Junction Maintenance and Dysregulation in Amyotrophic Lateral Sclerosis

The authors cover recent discoveries on axonal translation as a critical mechanism for neuronal maintenance/survival. They focus on two RNA binding proteins, transactive response DNA binding protein-43 (TDP-43) and fused in sarcoma (FUS), whose mutations cause amyotrophic lateral sclerosis and frontotemporal dementia.