NewslettersHuman Immunology NewsCholesterol Suppresses Human iTreg Differentiation and nTreg Function through Mitochondria-Related MechanismsBy Laurisa Dohm - March 28, 20230123Mechanistically, cholesterol induced the production of mitochondrial reactive oxygen species in naïve T cells, inhibiting the degradation of HIF-1α and unleashing its inhibitory effects on iTreg differentiation.[Journal Of Translational Medicine]Full Article