PRMT5 Methylating SMAD4 Activates TGF-β Signaling and Promotes Colorectal Cancer Metastasis

Through mass spectrometric, co-immunoprecipitation, and immunofluorescent assays, researchers found that oncogene protein arginine methyltransferase 5 (PRMT5) interacted with SMAD4 under TGF-β1 treatment.