TGR5 Agonist Inhibits Intestinal Epithelial Cell Apoptosis via cAMP/PKA/C-FLIP/JNK Signaling Pathway and Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis

Scientists synthesized a potent and selective Takeda G protein-coupled receptor-5 (TGR5) agonist OM8 with high distribution in intestinal tract and investigated its effect on intestinal epithelial cell apoptosis and ulcerative colitis treatment.