Deubiquitinase OTUD6A in Macrophages Promotes Intestinal Inflammation and Colitis via Deubiquitination of NLRP3

Researchers investigated the expression and role of ovarian tumor deubiquitinase 6 A (OTUD6A) in Inflammatory bowel disease. Bone marrow-derived macrophages were isolated from wild-type and Otud6a−/− mice to dissect molecular mechanisms.