The Transcription Factor Mef2d Regulates B:T Synapse–Dependent GC-T_FH Differentiation and IL-21–Mediated Humoral Immunity

Researchers found that Mef2d regulated Sh2d1a expression via DNA binding–dependent transcriptional repression, inhibiting SAP-dependent B:T synapse formation, and preventing antigen-specific CD4 T cells from differentiating into germinal center–T follicular helper (GC-Tfh) cells