VMP1 Prevents Ca²⁺ Overload in Endoplasmic Reticulum and Maintains Naive T Cell Survival

VMP1 promoted Ca2+ release from endoplasmic reticulum (ER) under steady state, and its deficiency led to ER Ca2+ overload, ER stress, and secondary Ca2+ overload in mitochondria, resulting in massive apoptosis of naive T cells and defective T cell response.