RNF31 Promotes Tumorigenesis via Inhibiting RIPK1 Kinase-Dependent Apoptosis

The authors demonstrated a cancer cell-intrinsic role of linear ubiquitin chain assembly complex (LUBAC) complex in tumor microenvironment to promote tumorigenesis. Lacking LUBAC component RNF31 in B16 melanoma cells but not immune cells including macrophages or dendritic cells greatly impaired tumor growth by increasing intratumoral CD8+ T cells infiltration.