Erythroferrone Exacerbates Iron Overload and Ineffective Extramedullary Erythropoiesis in a Mouse Model of β-Thalassemia

To analyze the effect of high erythroferron (ERFE) concentrations on hepcidin and iron overload in non-transfusion-dependent β-thalassemia, researchers crossed Th3/+ mice with erythroid ERFE-overexpressing transgenic mice.