Reserpine Maintains Photoreceptor Survival in Retinal Ciliopathy by Resolving Proteostasis Imbalance and Ciliogenesis Defects

To identify drug candidates to maintain photoreceptor survival, scientists performed an unbiased, high-throughput screening of over 6,000 bioactive small molecules using retinal organoids differentiated from iPSCs of rd16 mouse, which is a model of Leber congenital amaurosis type 10.