Vitamin D Reduces Pain and Cartilage Destruction in Knee Osteoarthritis Animals through Inhibiting the Matrix Metalloprotease (MMPs) Expression

Researchers investigated the therapeutic potential of vitamin D in OA Wistar rats induced by anterior cruciate ligament transection combined with medial meniscectomy. In ACLT + MMx-induced OA rats, pain severity, cartilage destruction, inflammatory cytokines, and MMPs were all measured.