Bone Marrow-Derived Extracellular Vesicles Carry the TGF-β Signal Transducer Smad2 to Preserve Hematopoietic Stem Cells in Mice

Investigators found that the extracellular vesicle (EV) inhibitor Calpeptin, when injected intravenously into mice, particularly affected the in vivo production of EVs carrying phosphorylated Smad2 in mouse bone marrow.